An en bloc resection was performed after histologic diagnosis of ameloblastic fibroma from an incisional biopsy specimen. Ameloblastic fibroodontoma afo is a rare, benign mixed odontogenic tumor that account for 1%3% of all odontogenic tumors 1,2. Ameloblastic fibroma af is a true mixed tumor, in which the epithelial and the ectomesenchymal elements are neoplastic. Ameloblastic fibroma af is a rare odontogenic tumor characterized by simultaneous neoplastic proliferation of epithelial and ectomesenchymal tissues without dental hard tissue formation. They are, the follicular pattern, plexiform pattern, acanthomatous. It may be either truly neoplastic or merely hamartomatous an odontoma. Sep 16, 2019 an ameloblastic fibroma is a fibroma of the ameloblastic tissue, that is, an odontogenic tumor arising from the enamel organ or dental lamina. Ameloblastic fibroma an overview sciencedirect topics. A manual search of all related oral pathology, maxillofacial and specialist and oral journals was performed. Ameloblastic fibroma of the mandible reconstructed with. This report describes a case of af in a 12yearold male identified during a routine radiographic exam for orthodontic treatment planning. Other mixed odontogenic lesions, such as ameloblastic fibroodontomas and odontomas share some clinical, radiographic and histologic similarities with ameloblastic fibroma.
There are six different patterns of manifestation for ameloblastoma under the microscope follicular, plexiform, acanthomatous, granular cell, desmoplastic and basal cell patterns. The ameloblastic fibroma is considered a true mixed odontogenic tumor, in which epithelial and mesenchymal tissues are neoplasics. Jun 10, 2014 educational video by unmc college of dentistry class of 2016 dental students. The exact cause of ameloblastic carcinoma is unknown.
The tumor predominantly affects the posterior region of the mandible 24 in patients during the first and second decades life. The ameloblastic fibroma is a slowly growing, mixed odontogenic tumour containing both epithelial and mesenchymal tissues. A rare case appearing as a mixed radiographic image. According to the 2005 who classification of odontogenic tumors, it is defined as a benign tumor that resembles ameloblastic fibroma but contains enamel and dentin. Ameloblastic fibroma af is a rare, slowgrowing benign neoplasm, comprised of tissues of odontogenic origin. The first case of afs was reported in 1887 by heath. Management of the lesion includes enucleation of the tumour and longterm followup. In neoplastic cases, it may be labeled an ameloblastic fibrosarcoma in accord with the terminological distinction that reserves the word fibroma for benign tumors and assigns the. Pdf ameloblastic fibroma is a rare odontogenic tumor comprising neoplastic epithelial and. Ameloblastic fibroma af is an uncommon benign odontogenic tumour, with both epithelial and mesenchymal neoplastic proliferation. There are six different patterns of manifestation for ameloblastoma under the microscope. Introduction the ameloblastic fibroma af is a tumour composed of odontogenic ectomesenchyme resembling the dental papilla with epithelial strands and nests similar to the dental lamina and enamel organ, but with no.
Ameloblastic fibroma of maxilla and maxillary sinus a case report. It is usually slow developing and is usually seen in young persons with a. The patient is under long term followup with no signs of recurrence. May 20, 2017 odontogenic tumours can pose significant diagnostic challenges for the pathologist because of their relatively low incidence, somewhat overlapping histology and subtle differentiating features. It occurs most frequently in the posterior region of the mandible, while its occurrence in the maxilla is extremely rare. The panoramic radiography revealed a welldefined multilocular mixed image. Pdf ameloblastic fibroma and ameloblastic fibrosarcoma. Ameloblastic fibroma af is an uncommon benign odontogenic true mixed tumor comprising. Ameloblastic fibroma and afo are rare in all domestic species but are the most commonly diagnosed odontogenic neoplasm in the mandibles of young cattle. The aim of this study was to describe a case of a second decade of life patient, asymptomatic, that was diagnosed the lesion above cited, being latter carried surgical treatment for tumor removal.
Ameloblastic fibroma definition of ameloblastic fibroma. Oct 31, 2008 ameloblastic fibromas are neoplasms of odontogenic epithelium and mesenchymal tissues, and as such are categorized as mixed odontogenic tumors. Ameloblastic fibroma is a rare benign mixed epithelial and mesenchymal odontogenic tumour as it contributes to approximately 2% of all odontogenic tumours. Since then only 91 cases have so far been reported. As it is a very rare type of tumor that is located in the mandible or maxilla region. Oct 31, 2008 ameloblastic fibroma ameloblastic fibroma nelson, brenda. Ameloblastic carcinoma nord national organization for rare. A large ameloblastic fibroodontoma of the right mandible. In support of this viewpoint, trodahl and carr et al. Ameloblastic fibromas are rare benign odontogenic tumours, which appear prefererentially in adolescents and young adults. Related articles ameloblastic fibrodentinoma ameloblastic fibroma ameloblastic fibroodontoma dentinoma odontogenic tumors. Purpose to integrate the available data published to date on ameloblastic fibromas af and ameloblastic fibrosarcomas afs into a comprehensive analysis of their clinicalradiological features.
Classification, histopathology, and clinical behavior in man and domesticated animals. Ameloblastic fibroma af is known as a tumour of odontogenic origin characterised by the proliferation of both epithelial and mesenchymal odontogenic tissues without the formation of hard tissue structures. It is also radiolucent and expansile so that its clinical and radiographic pattern will be similar to an ameloblastoma and to an odontogenic myxoma fig. Nov, 2014 ameloblastic fibroodontoma afo is a quite rare, mixed odontogenic tumour generally seen in the early stages of life. Most authors now agree that ameloblastic fibroodontoma is a separate entity but it can be histologically indistinguishable from immature complex odontoma. Jan 17, 2017 there are six different patterns of manifestation for ameloblastoma under the microscope. Khalili m, shakib pa 20 ameloblastic fibrosarcoma of the upper jaw. Ameloblastic i broma of the jaw is a rare, benign mixed odontogenic tumor, having little tendency for local invasion and a low recurrence rate. Odontogenic epithelium without odontogenic mesenchyme 1. Ameloblastic fibroma definition of ameloblastic fibroma by. Aug 04, 2019 an ameloblastic fibroma is a fibroma of the ameloblastic tissue, that is, an odontogenic tumor arising from the enamel organ or dental lamina.
It constitutes 2% of odontogenic tumours, occurring at any age, but has a predilection to present in the first two decades of life. A single ameloblastic odontoma was identified in a 20 monthold dog case no. Among the different patterns, follicular type is the most common histological type of ameloblastoma. Ameloblastic fibroma af is a benign tumor of mixed odontogenic origin, which affects predominantly young individuals. Ameloblastic fibroma is a rare mixed odontogenic tumor of the jaw. It often occurs in the first or second decade of life.
It is characterized by epithelial islands and cords immersed in ectomesenchyme that mimics the dental. Wright for his help in histopathologic diagnosis and for his comments on the microscopic. Ameloblastic fibroma af is an uncommon benign odontogenic true mixed tumor comprising neoplastic epithelial and mesenchymal tissues. Ameloblastic fibroma in a young adult kumar r m, bavle r, srinath. Generally is asymptomatic, however the biggest lesions can be associated to pain and swelling.
Odontogenic epithelium with odontogenic ectomesenchyme with or without hard tissue formation 1. Kobayashi k, murakami r, fujii t and hirano a 2005 malignant transformation of ameloblastic fibroma to ameloblastic fibrosarcoma. Ameloblastic fibroodontoma associated with a retained molar. Despite similar histology, the biological behaviour and appropriate therapy differ significantly between entities and accurate diagnosis is therefore essential. Ameloblastic fibroma, differential diagnosis, incidental finding, mixed image, radiographic features. Ameloblastic fibroma af is a benign tumor of mixed odontogenic origin, which affects predominantly young. The ameloblastic fibroma is a rare neoplasm that occurs mostly in children and teenagers. Department of oral pathology, school and hospital of stomatology, peking university, beijing, china. In the past, it was suggested that these lesions represented a spectrum of a single entity, with ameloblastic fibromas, the least differentiated of the tumors, maturing and. Pereira kd, bennett km, elkins tp, qu z 2004 ameloblastic fibroma. Ameloblastic fibromas appear as unilocular lucent mandibular lesions, most frequently in the posterior mandible, and are usually associated with impacted teeth, centered on the unerupted crown.
Ameloblastic fibroodontoma afo is a rare benign mixed odontogenic tumor that usually arises in the maxilla and mandible. It is usually associated with developing teeth and occurs predominantly in children and adolescents. An ameloblastic fibroma is a fibroma of the ameloblastic tissue, that is, an odontogenic tumor arising from the enamel organ or dental lamina. Inductive fibroameloblastoma was observed in four cats case nos. Ameloblastic fibro sarcoma afs is one of the rare histopathology variety of odontogenic tumours. Ameloblastic fibroma and ameloblastic fibrosarcoma. In many cases, such lesions are found on radiographic evaluation of patients in whom eruption of teeth is. The ameloblastic fibroodontoma afo is a rare benign odontogenic defined as a tumour with the general features of ameloblastic fibroma but that also contains enamel and dentin. The exact underlying cause of the ameloblastic fibroma is not known well yet. Ameloblastic fibroma of the maxilla with bilateral. Pdf after reading the text an aggressive ameloblastic fibroma in a. Ameloblastic fibroodontoma is a benign epithelial odontogenic tumour with odontogenic mesenchyme exhibiting the histologic characteristics of ameloblastic fibroma and complex odontoma. Therefore, a histopathological examination is essential.
Ameloblastic fibroma and ameloblastic fibroodontoma the ameloblastic fibroma is a slow growing, benign odontogenic neoplasm composed of mesenchyme that resembles dental papilla and an epithelial component that resembles the dental lamina and immature enamel organ. This number includes both denovo and sarcomatous transformation from preexisting ameloblastic fibroma, occurring in different sites. They are usually encountered in children, emphasizing it as an important diagnostic consideration. Soukup1 abstract a 4yearold spayed female golden retriever was presented for evaluation of a rostral maxillary gingival mass. Pereira kd, bennett km, elkins tp, qu z 2004 ameloblastic fibroma of the maxillary sinus. Wb saunders shafer wg, hine mr, levy bm 1983 a textbook of oral pathology. Ameloblastic fibroma af is a rare tumor, accounting for 2% of all odontogenic tumors, characterized by simultaneous neoplastic proliferation of mesenchymal and epithelial components, with no formation of hard dental tissues. Ameloblastic fibroma usually appears as painless swelling of the jaw in the posterior region of the mandible. Gingival ameloblastic fibrodentinoma report of a case in a child. It is usually slow developing and is usually seen in young persons with a mean age between 8 and 12 years. The present case report describes a 40yearold patient with an ameloblastic fibroma in.
Ameloblastic fibroma, is a mixed odontogenic tumor, which commonly affects young children under the age of 20 years, with the mandibular premolarmolar. Afs is exceedingly rare, with ameloblastic fibroma af is a rare, slowgrowing benign neoplasm, comprised of tissues of odontogenic origin. Afs is exceedingly rare, with ameloblastic fibroma af is a true mixed tumor, in which the epithelial and the ectomesenchymal elements are neoplastic. Ameloblastisches fibrom im oberkiefer springerlink. Veterinary pathology maxillary ameloblastic fibroma in a. It is regarded as the malignant counterpart of ameloblastic fibroma af.
It is characterized by epithelial islands and cords immersed in ectomesenchyme that mimics the. Af appearing as a mixed radiographic image is very rare. In this brief report, we report a case of af in the context of its high cellularity on histopathological examination. They, therefore, appear very similar to unilocular ameloblastomas. Odontogenic tumours are rare lesions and many nonspecialist histopathologists will not have seen many during their working lifetime. If dentine is identified in the specimen, then the lesion is classified as an ameloblastic fibrodentinoma and tends to occur in young children. Ameloblastic fibroma af is an extremely rare true mixed benign tumor that can occur in either the mandible or the maxilla, but is most frequently found in the posterior region of the mandible. To integrate the available data published to date on ameloblastic fibromas af and ameloblastic fibrosarcomas afs into a comprehensive analysis of their clinicalradiological features. Hybrid odontogenic tumor of calcifying odontogenic cyst and ameloblastic fibroma. Researchers speculate that genetic and immunologic abnormalities, environmental factors e. Ameloblastic fibroma of maxilla and maxillary sinus a case. Ameloblastoma malignant ameloblastoma ameloblastic carcinoma 2. Afs is exceedingly rare, with ameloblastic fibroma is a fibroma of the ameloblastic tissue, that is, an odontogenic tumor arising from the enamel organ or dental lamina. A survey of epithelial odontogenic tumors and cysts in.
Unusual microscopic changes of ameloblastic fibroma and. Frequent signs of this tumour are asymptomatic swelling, delayed tooth eruption and mixed radiological appearance within welldefined borders. Ameloblastic fibroodontoma radiology reference article. Histopathological examination revealed ameloblastic fibroma. Ameloblastic fibrosarcoma afs is an aggressive odontogenic neoplasm featuring malignant mesenchymal stroma in addition to an ameloblastic epithelial component, and is hence considered to be the malignant counterpart of ameloblastic fibroma af. Apr 01, 2017 ameloblastic fibrosarcoma of the jaws. But it is reported that mandible is more prone to the adoption of these tumors which accounts for 8390% of the cases. Ameloblastic fibroma or fibroameloblastoma was observed in cats case nos. Marx, in current therapy in oral and maxillofacial surgery, 2012. Aug 01, 2003 aspiration cytology of ameloblastic fibroma. It constitutes only approximately 2% of odontogenic tumors and is defined by the world health organization who as neoplasm composed of proliferating odontogenic epithelium embedded in cellular. Jul 07, 2019 an ameloblastic fibroma is a fibroma of the ameloblastic tissue, that is, an odontogenic tumor arising from the enamel organ or dental lamina.
Unusual ameloblastic fibroma and ameloblastic fibroodontoma e477 introduction ameloblastic fibroma af is an uncommon benign odontogenic neoplasm, which is described by the proliferation of both the odontogenic epithelium and the mesenchyme. A case report hyunho chang, dds, msd, phd michael s. However, most cases were diagnosed as primary malignant processes 15. A diagnostic challenge aspiration cytology of ameloblastic fibroma.
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